SBR: My Sister’s Keeper has a very interesting premise in the life a child conceived to be a genetic donor to her sibling. It doesn’t deal with it well. The conflicts are unbelievable, they undermine the real conflict one would face in situations like these, the medical issues misrepresented, the twists are too contrived and some of the most important characters do not make sense. The side dose of romance makes it worse. As an Amazon reviewer rightly pointed out, in real circumstances, it is more likely that a minor will have to go to the court to allow her to donate her organ, rather than to stop it from being done against her wishes because the parents want so!
It does manage to be a good tear-jerker once in a while. But it is not a good book dealing with a difficult issue.
To read or not to read: Yes, if a light tear-jerker reading is what you are looking for. Not for the subject it pretends to address.